Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Phenylmethylsulfonyl Fluoride
Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.
MilliporeSigma™ Calbiochem™ Piperlongumine
A cell-permeable, orally bioavailable natural product isolated from the plant species, Piper longum L, which selectively induces cell death in cancer cells that express both wild-type and mutant p53.
MilliporeSigma™ Calbiochem™ AEBSF, HCl ≥99% by HPLC
Specific irreversible inhibitor of serine proteases
MilliporeSigma™ Calbiochem™ PERK Inhibitor I, GSK2606414
GSK2606414 is a cell-permeable, highly potent inhibitor of EIF2AK3/PERK (IC50 = 0.4 nM; [ATP] = 5 μM). Targets PERK in its inactive DFG conformation at the ATP-binding region.
MilliporeSigma™ Calbiochem™ o-Phenanthroline
A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells.
MilliporeSigma™ Calbiochem™ PPARβ/δ Antagonist, GSK3787
The PPARβ/δAntagonist II, PT-S58, also referenced under CAS 188591-46-0, controls the biological activity of PPARβ/δ. This small molecule/inhibitor is primarily used for Biochemicals applications.
MilliporeSigma™ Calbiochem™ Phosphatase Inhibitor Cocktail Set III
Phosphatase Inhibitor Cocktail Set III is a ready to use cocktail of four phosphatase inhibitors for broad-spectrum inhibition of both serine/threonine and protein tyrosine phosphatases.
MilliporeSigma™ Calbiochem™ TRPM Antagonist, M8-An
A cell-permeable, readily bioavailable 2-picolinamide derivative that acts as a highly potent antagonist of transient receptor potential cation channel subfamily M member 8 (TRPM8; IC50 =
MilliporeSigma™ Calbiochem™ RIPK3 Inhibitor, GSK'872
A cell-permeable, selective inhibitor of RIP3-selective kinase with >1,000-fold selectivity over a vast majority of more than 300 other kinases.
MilliporeSigma™ Calbiochem™ PFKFB3 Inhibitor III, YN1
A cell-permeable, potent and competitive inhibitor of fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 670 nM).
MilliporeSigma™ Calbiochem™ PLD Inhibitor, FIPI
The PLD Inhibitor, FIPI controls the biological activity of PLD. This small molecule/inhibitor is primarily used for Membrane applications.
MilliporeSigma™ Calbiochem™ JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1
A cell-permeable, superior inhibitor of Jumonji C domain histone lysine demethylase. About 30 fold more potent than IOX1 (EC50 = 3.8 μM for KDM4A in HeLa cells vs. 100 μM for IOX1).
MilliporeSigma™ Calbiochem™ Glutaminase Inhibitor II, BPTES
A cell-permeable, potent, selective, reversible, and uncompetitive allosteric inhibitor of kidney-type glutaminase (GLS1). Does not affect the activity of liver glutaminase.
MilliporeSigma™ Calbiochem™ Pro-survival Compound, DDD00033325
A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background with equal or higher potency than Y-27632.
MilliporeSigma™ Calbiochem™ Luciferase Substrate, CycLuc1
A synthetic cyclic alkylaminoluciferin with properties superior to D-luciferin. Binds to luciferase with higher affinity.